Products

Nanogaine

Nanogaine is a hairloss treatment that has been shown to: Help to ward off hairloss by inhibiting Superoxide and Sebum output - Stimulate hair growth by expanding the Anagen (growth) phase and shortening the Telogen (resting) phase of the hair- Reduce inflammation in the hair follicle.

What is Nanogaine?

Nanogaine is a hairloss treatment that has been shown to:

Help to ward off hairloss by inhibiting Superoxide and Sebum output
Stimulate hair growth by expanding the Anagen (growth) phase and shortening the Telogen (resting) phase of the hair
Reduce inflammation in the hair follicle

Long-term Use

It is a fact of any hair regrowth product, whether topical or oral, that it's application must be ongoing to maintain results.

Both Minoxidil and Nanogaine work by releasing the Nobel Prize-winning Nitric Oxide molecule (NO), which acts as a chemical messenger to the hair follicles. In fact, that is what the NO stands for in Minoxidil and Nanogen. Minoxidil is unfortunately only soluble in alcohol solutions and consequently causes incredibly dry and flaky scalp over long-term use. Furthermore, this drying effect damages the hair follicle.

Nanogaine represents a breakthrough in hair regrowth technology as its formulation is water soluble and thus can be used for years without any reported adverse effects. With Nanogaine, you get all the benefits of Nitric Oxide, without the downsides of an alcohol-based product.

The life cycle of a hair

In a normal scalp, approximately 90% of hairs are in the Anagen phase and 10% in either the Catagen or Telogen phase. In cases of Alopecia, the number of hairs in the Anagen phase drops, while the number of hairs falling out (Telogen phase) rises.

Clinical trials show that Nanogaine can increase the number of hairs in the Anagen phase by +15%, at the same time decreasing the number of hairs in the Telogen phase.

Regrow your hair with Nanogaine

The Nitric Oxide (NO) pathway exists within every hair cell. Increased presence of intracellular Nitric Oxide has been shown to increase the size and section of the hair follicle (left)

Conversely, Peroxynitrite has been shown to be detrimental to the health of the hair follicle.

Superoxide Dismutase (SOD) therefore has a double hair growth stimulation effect - more NO and less Peroxynitrite.

Without Nanogaine:

	Nitric Oxide (NO) occurs naturally in the scalp and is essential for healthy hair growth.
	Free Radicals are ever-present in the scalp and cause cell damage.
	Peroxynitrite is formed when a reaction occurs between NO and free radicals. Peroxynitrite has been shown to be detrimental to the health of the hair follicle.
	Superoxide Dismutase (SOD) is a naturally occuring enzyme, present in every cell and specialising in the quenching of large volumes of the free radicals which attach to Nitric Oxide.

How Nanogaine Works:

Nanogaine contains the bio-mimetic form of SOD which is present in high concentration to boost the natural free radical scavengers within every hair cell.

What else does Nanogaine contain other than patented 'bacterial filtrate SOD peptides'?

Capilecti™ has been shown to expand the Anagen (growth) phase and shorten the Telogen (resting) phase by 17%. Capilecti is a lectin-like glycoprotein helping to agglutinate hair follicle cells together.

Lo-Seb™ is a complex of homotaurine, bacterial filtrate peptides and marine derived sulphomucpolysaccharide extract. Lo-Seb reduces sebum output by 16% and is effective in normalising Seborra often implicated in alopecia. Lo-Seb also has been shown to increase the percentage of hair in the Anagen (growth) phase by 15% (from 74.6% to 85.5%)

Nanogaine increases the size of the hair follicle, expanding the Anagen phase and shortening the Telogen phase.

These microscope photographs demonstrate the 'lectin-like' effect Nanogaine has on the cells, that is, it contains a glycoprotein that agglutinates (clumps together) the hair follicle cells, assisting growth.

Clinical Research behind Nanogaine

Topical application test

The hair of the lumbar region (small 5cm patch) of six C3H mice was cut and 0.1ml of SOD extract was applied twice a day, until hair growth was observed. The area of hair growth was monitored with an image analysing apparatus
on days 14, 21 and 28 following the start of the test.

At 1% concentration of SOD, hair growth response was observed in all cases after 14 days and hair growth rate was observed in all areas of treatment. At 0.5% concentration, hair growth response was observed in all cases
and hair growth rate was 90%. In comparison, Minoxidil (2% Rogaine, Upjohn) showed hair growth response
for 5 out of the 6 animals in 28 days and hair growth rate was at 57%

In Vitro test

It has been shown that Minoxidil increases the DNA synthesis of skin hair follicle and the synthesis of keratin in the hair follicle (Buhl AE et al., J Invest Dermatol 1991 May; 96(5):73S-74S) so it was decided to use the same test for Superoxide Dismutase for a fair comparison. Addition of only 5-10 microM of SOD extract provoked hair follicle protein synthesis which was 100-200% higher than that of Minoxidil (2%)

We are aware that Minoxidil is usually used at 5% concentration or higher. Nanogaine is formulated with 2% SOD in addition to it's other actives such as Lo-Seb TM and Capilecti. Nanogaine can be used concurrently with Minoxidil therapy.

A simple search on the Google engine "SOD + Hairloss" will provide multiple references to the other respected sources who have tested SOD for applications in hair loss therapy. Indeed there have been expensive patent fights over this particular ingredient.

Here is a quote from the respected US website Hairlosstalk which we are comfortable quoting as they do NOT stock Nanogaine (we only supply EU):

"SOD's - Also known as Super Oxide Dismutase, these hair loss treatments work by handling the immune response which occurs as a result of excessive DHT in the follicle. When cells sense a foreign body, they release Super Oxide, which typically help defend the body against invading viruses, cells, and foreign tissues. SOD's reduce the presence of this Super Oxide, thus reducing the body's desire to reject the follicle. It's yet another "angle" proven to work in fighting hair loss. SOD's are kind of a hybrid treatment because they also have growth stimulation properties, as well as anti-inflammatory properties."

Frequently Asked Questions

How long will a pack of Nanogaine last?
Each pack of Nanogaine is designed to last 1 month of application.
How do I apply nanogaine, and at what times are optimal?
Full details on how to apply are printed on the carton.
When should I expect to see results?
The time taken to see result varies between individual and for some, little results are achieved.

It would be the same for users of Minoxidil. Some people respond excellently and others do not respond at all. However in all cases, users would be advised to allow at least 3 months of application in order to assess results.
Do I need to use Nanogaine forever?
Yes. Every clinically proven hair loss treatment without exception MUST be used indefinitely. For most people this is not as daunting as it first sounds – especially with Nanogaine.

First off, Nanogaine is water-based, so unlike Minoxidil, it does not dry the hair and scalp even with long-term use. Secondly, not being a tablet whose effects are systemic, it does not have side effects.

Besides a lot of people just want to extend the ‘life’ of their hair for a further 10 years or just slow down the loss, so you don’t have to use it forever, just if you want to maintain result you will do.

Applying Nanogaine takes less time that putting in your contact lenses, just 5 minutes or less.

Are there any side effects from using Nanogaine?
This is the greatest feature of Nanogaine. Unlike Minoxidil, which must be dissolved in ethanol (alcohol), the Nanogaine actives are water-soluble. This was our breakthrough. This means that you can get all the benefit from 'topical NO supplementation' without drying the hair. It is a very important factor when one remembers that Minoxidil must be used for the rest of your life, or hair regrown/stopped from falling out, will then fall out. Nanogaine is a long-term choice for people who want to have hair and have it healthy looking/feeling too.

Can you use nanogaine alongside Minoxidil?
Yes you can. Naturally, there will be some drying because of the alcohol in the minoxidil solution. Some people use Nanogaine day and night and use Minoxidil once a day also. You may like to use an oily hair gel or cream such a "brylcream" to avoid the worst 'straw-hair' from long-term minoxidil use.
What if I use the night ampoule in the day (or vice-versa) what are the effects?
No adverse affects at all. It is just that at night, your scalp will produce more sebum and the night formula is designed to slow sebum production and hence the optimum conditions will be obtained by using the ampoules in the correct order.
What is shedding?
When hair growth is stimulated, a large amount of follicles move into the Anagen phase from the Telogen phase simultaneously, which has the obvious consequence of hairloss during the initial phase of treatment (shedding). Do not be concerned. Although it may sound counter-intuitive, more than usual hairloss is usually an indication the formula is working according to the published studies. The new hair that replaces that just lost will be thicker, stronger and with more colour.